Well, I tried it on OSX Lion. After downloading a bunch of dependencies, I finally was able to launch the program... and crashed in about 5 seconds. Tried it again, got the train to load, but for some reason the train would just lurch forward even if it was on emergency brake. After stopping the train and closing the doors before moving, the train kept making a squeaking noise and wouldn't go over 30 MPH. Not to mention that every time you put the power handle to Neutral, the train would just slow down and stop as if the brakes were applied. The exterior didn't work at all. After waiting about 50,000 hours after pressing F2, the exterior showed up and openBVE promptly froze. Now I just use Boot Camp to install Windows 7 and openBVE works fine after that, provided that you update to the latest drivers.
However, I do have a bit of good news. If anybody is looking for a new laptop, a decent Ivy Bridge processor and Intel HD Graphics 4000 is enough to run the F line at 25-30 FPS. However, I had to use 1280x800 resolution, which was the highest supported by my screen, so don't expect to get a 1080P laptop and have the same performance.