Run as administrator doesn't help, I'm already up on that, this issue occurs with the R142, R179, and R15 so far that I've used, No personal discrepancies with the models themselves. As far as my computer being able to handle the high textures, it did so before I installed the graphics card, I also run TS2013 which is very demanding in the high-textures department and it does a great job there. I'm not able to take screenshots with MS Paint, full screen or windowed mode, but no problem with MSTS and TS2013, another problem I need to figure out. Here's my home built system.
Windows 7 Home Premium Service Pack 1
AMD Sempron 140 Processor 2.70 GHz
4.00 GB (stepping up to 8GB)
X64bit
1GB Hard Drive
MSi Radeon HD 6450 Graphics w\ 1GB memory
Its been doing real good running MSTS, TS2013, and OpenBve's programs, right now I'm just looking for answers to issues concerning the graphics card dealing with some of OpenBve transit equipment textures.